Fig 1: Annexin A1 reduces proliferation and promotes migration of cancer cells in vitro and diminishes xenograft growth in vivo. A and B: PCR evaluation of Anxa1 (A) or S100-A11 (B) transcripts in Lewis lung carcinoma (LLC) cells transfected with empty vector [control (CTL)] or shRNA targeting Anxa1. Mann-Whitney U-test was used. C: proliferation rate of control and Anxa1-deficient cells. Two-way ANOVA was used. D: photograph of the Boyden chamber (left) and microphotographs (right) of crystal violet-stained control and Anxa1-deficient LLC cells subjected to 48 h Transwell migration assay. E: density quantification of migrated cells in microphotographs from the experiment in D. Each circle and square represents 1 field of view. Mann-Whitney U test was used. F: tumor growth curves of control and Anxa1-deficient LLC cells implanted into flanks of C57BL/6 mice. Two-way ANOVA was used. a.u., arbitrary units; n.s., not significant.
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